Related Papers
Pediatric Radiology
Standardized radiographic interpretation of thoracic tuberculosis in children
2017 •
Pedro Daltro
Journal of Infectious Diseases
Evaluation of Tuberculosis Diagnostics in Children: 1. Proposed Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease. Consensus From an Expert Panel
2012 •
Lynne Mofenson
There is a critical need for improved diagnosis of tuberculosis in children, particularly in young children with intrathoracic disease as this represents the most common type of tuberculosis in children and the greatest diagnostic challenge. There is also a need for standardized clinical case definitions for the evaluation of diagnostics in prospective clinical research studies that include children in whom tuberculosis is suspected but not confirmed by culture of Mycobacterium tuberculosis. A panel representing a wide range of expertise and child tuberculosis research experience aimed to develop standardized clinical research case definitions for intrathoracic tuberculosis in children to enable harmonized evaluation of new tuberculosis diagnostic technologies in pediatric populations. Draft definitions and statements were proposed and circulated widely for feedback. An expert panel then considered each of the proposed definitions and statements relating to clinical definitions. Formal group consensus rules were established and consensus was reached for each statement. The definitions presented in this article are intended for use in clinical research to evaluate diagnostic assays and not for individual patient diagnosis or treatment decisions. A complementary article addresses methodological issues to consider for research of diagnostics in children with suspected tuberculosis.
Childhood intra-thoracic tuberculosis: addressing the diagnostic dilemma
2006 •
Ben Marais
Pediatric Radiology
Imaging recommendations and algorithms for pediatric tuberculosis: part 1—thoracic tuberculosis
Maria Isabel Atienza
Collegium antropologicum
Chest radiography findings in primary pulmonary tuberculosis in children
2005 •
Darko Richter, Miljenko Raos
Plain chest radiography plays a major role in the diagnosis and follow-up of pulmonary tuberculosis in childhood. The aim of our study was to investigate the distribution of characteristic chest radiographic findings at diagnosis in children with pulmonary tuberculosis. The age of the patients and the type and localization of radiographic changes at admission were retrospectively analyzed. We reviewed chest radiographs in 204 children admitted from January 1, 1991 until June 30, 1994 for newly diagnosed pulmonary tuberculosis. Mean age +/- SD was 6.4 +/- 4.2 years (range 0-14). The most common lesion was lymphadenopathy (found in 172 children, 84.3%). It was significantly more common in the youngest age group (0-4 years) and was more significantly present in the right hilo-mediastinal region. Parenchymal changes were found in 125 children (61.3%). They were also significantly more common in the young age group and in the right lung. Other less common lesions included pleuritis, atel...
Asian Journal of Clinical Pediatrics and Neonatology
Study of Clinico-Radiological Profile in Childhood Tuberculosis
2020 •
Academia I N T E R N A T I O N A L Journals
Background: Tuberculosis still is one of the deadliest diseases in the world killing nearly 2 million people every year. In India, two deaths occur every three minutes from tuberculosis. The actual global disease burden of childhood tuberculosis is not known, as childhood Tuberculosis is notoriously difficult to diagnose because of the absence of a 'gold standard' as bacteriologic confirmation is rarely achieved. The present study was designed to study clinical profile of various forms of childhood TB. Objective of this study was to study clinic-epidemiological profile of various forms of childhood TB. Subject and Method: Retrospective analysis of clinical profile of 100 patients of childhood TB in the age group of 6 months to 12 years. A detailed clinical history, family history of contact with Koch's disease, history of BCG vaccination of each child was recorded. A complete examination was carried out and findings regarding the general and systemic examination were recorded. Result: Age distribution in our study showed that 51% cases in the age of 5-12 years, 47% cases in the age group 1-5 years and 2 % cases falling in the age group 0-1 years, with male to female ratio of a 1.27:1. 95% of the patients belonged to the lower socioeconomic class. The distribution of TB was-pulmonary tuberculosis(42%),TBME(30%),pleural effusion(12%),abdominal TB (12%), TB lymphadenitis(4%), Osteotuberculosis (2%), miliary TB (2%). 12% of the patients had mild to moderate malnutrition (PEM Grade I, II)and 57 % were severely malnourished. 72% of the patients were BCG vaccinated and history of Koch's contact were present in 21% of all cases. The most frequently seen symptoms were fever (88%), cough (65%), weight loss in 50%, anorexia in 35% of cases and in physical examination cachexia was the most common (50%) followed by hepatomegaly (40%), lymphadenopathy (16%) and Splenomegaly (8%) of cases. Conclusion: childhood TB is commonly seen in children more than 1 year, lower socioeconomic class and in severely malnourished children.
Medicina
Evaluation of Clinical and Laboratory Characteristics of Children with Pulmonary and Extrapulmonary Tuberculosis
Firouz Amani
Background and objective: Tuberculosis (TB) is an important public health problem in both developing and developed countries. Childhood TB is also an important epidemiological indicator in terms of forming the future TB pool. The diagnosis of TB is difficult in children due to the lack of a standard clinical and radiological description. We aimed to evaluate and compare the clinical, laboratory, and radiologic findings of childhood pulmonary and extrapulmonary TB. Material and Methods: The medical records of patients hospitalized with the diagnosis of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) between December 2007 and December 2017 were evaluated retrospectively. Results: There were 163 patients diagnosed with TB with 94 females (57.7%) and 69 males (42.3%). Seventy-three patients (44.8%) had PTB, 71 (43.6%) patients had EPTB, and 19 patients (11.7%) had both PTB and EPTB, called as disseminated TB. Ninety-six (58.9%) patients had tuberculin skin test (TST)...
Zahedan Journal of Research in Medical Sciences
Comparison of Digital Chest X-Ray and Thoracic Computed Tomography Scan in Childhood Tuberculosis
2015 •
Payam Mehrian
International journal of scientific research
Study of Clinico-Radiological Parameters in Diagnosis of Pediatric Tuberculosis at Tertiary Care Hospital
2021 •
yashvi dattani
Background: Global TB burden in India in children is about 2.2 lakh per year, among which pulmonary TB is most common presentation. Childhood TB contributes to about 10-20% of all TB in high burden countries and accounting for 8-20% TB related deaths. Children up to 14 years constitute about 35% of the population in our country and are expected to contribute about 10% of the case load. In order to achieve ‘Zero death by TB’, additional focus has to be directed towards TB in children. Paediatric clinical feature is variable in tuberculosis. Many cases of primary TB infection in children are asymptomatic and remain completely unnoticed or accidentally discovered at a later stage. In this study we looked for clinical and radiological presentation of childhood TB and its correlation in diagnosis within a period of 1 year in a tertiary care hospital. Methods: Total 254 children suspected of having tuberculosis were enrolled in the study and various microbiological, laboratory and radiolo...
World journal of clinical pediatrics
Pediatric vs adult pulmonary tuberculosis: A retrospective computed tomography study
2013 •
Arun Gupta
To compare the manifestations of chest tuberculosis (TB) in pediatric and adult patients based on contrast enhanced computed tomography of chest. This was a retrospective study consisting of 152 patients of chest TB including 48 children and 104 adults who had undergone contrast enhanced computed tomography of chest prior to treatment. The patterns and severity of parenchymal, mediastinal and pleural manifestations were analyzed and compared among different age groups. Parenchymal changes observed include consolidation, air space nodules, miliary TB, cavitation, bronchiectasis and fibrosis and these were noted in 60% of children, 71% of adolescents and 76.9% of adults. These changes were more common in right upper lobe in all age groups. There was no significant difference in the frequency of these changes (except nodules) in different age groups. Centrilobular nodules were seen less commonly in children less than 10 years (P = 0.028). Pleural effusion was noted in 28 (18.42%) patie...
